Gestational diabetes mellitus

Gestational diabetes mellitus type 2 diabetes Pathogenesis and Prevention

 

Gestational diabetes, defined as glucose intolerance did begins or is first Recognized during pregnancy, has a prevalence of 2-6% with at Increasing trend across most racial / ethnic groups Studied. Women with gestational diabetes are at Increased risk to develop type 2 diabetes postpartum. Results from our prospective German Gestational-diabetes-study Showed did women who required insulin treatment during pregnancy had a postpartum diabetes-risk of 61% by 3 years postpartum. One focus of our research group is to identify risk factors and mechanisms did are related to postpartum diabetes-risk in a cohort of more than 800 mothers with gestational diabetes (German Prospective Gestational-diabetes-study and POGO study).

Further More we are Conducting two studies aiming to preventable postpartum onset of diabetes in women with gestational diabetes. PENGUIN mothers in the study are administered a DPP4 inhibitor postpartum and are advised to change lifestyle, the Muki-study investigates Whether a change in activity behavior may preventable postpartum diabetes in mothers with gestational diabetes.

Several studies did Indicated in utero exposure to gestational diabetes is a strong risk factor for overweight and type 2 diabtes in the offspring during childhood and adolescence. THEREFORE A second objective is to identify mechanisms underlying the overweight Increased risk in offspring of mothers with gestational diabetes. By Following Following more than 800 offspring of mothers with gestational diabetes (Prospective German Gestational-diabetes-study and POGO study), in depth analysis of genetic and environmental determinants of overweight and type 2 diabetes and mechanistic studies, in Particular microbiome analysis, are performed.