Type 1 diabetes prevention
Diabetes prevention has stopped aims to prevent
the development of islet autoimmunity in children with a familial or genetic
risk (primary prevention) or the extent of beta cell destruction in
antibody-positive children and adults (secondary prevention). Immune
interventions have the goal to reduce the autoreactive immune response and to
preserve the remaining beta cell mass (tertiary prevention after onset of type 1
diabetes).
The efficacy of therapeutic strategies for diabetes prevention is
not yet definitively proven. Previously completed studies show promising
results, but since dose-finding, age-dependent effect and safety of these
therapies have not been researched, these therapies are not routinely available.
So diabetes prevention takes place in controlled studies in which patients can
participate with newly manifest diabetes or people with increased risk of
diabetes.
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